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Histone H2A type 1-B/E

Names and Origin

Protein namesHistone H2A type 1-B/E
Alternative name(s):Histone H2A.2,Histone H2A/a,Histone H2A/m
Genes1. PRH1 EntrezGene:5554
2. PRH2 EntrezGene:5555
OrganismHomo sapiens
TaxonomyEukaryota > Opisthokonta > Metazoa > Eumetazoa > Bilateria > Deuterostomia > Chordata > Craniata > Vertebrata > Gnathostomata > Teleostomi > Euteleostomi > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda > Amniota > Mammalia > Theria > Eutheria > Boreoeutheria > Euarchontoglires > Primates > Haplorrhini > Simiiformes > Catarrhini > Hominoidea > Hominidae > Homininae > Homo

Sequence Attributes

IdentifierNameAliasesSequence lengthMolecular massSequence
P04908Canonical sequence13014135HSPW:PE90567/1

Go Annotations

The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: 1. Molecular function 2. Biological process 3. Cellular component


A variety of groups, including UniProtKB curators, use GO terms to annotate gene products in a computationally tractable manner. UniProt lists the annotated GO terms in the 'Function' section; the GO terms from the 'Cellular component' category can also be seen in 'Subcellular location' section. The project that made the annotation is shown as the 'Source', and a click on this label will display the supporting type of evidence. When available, a link to the relevant publications is provided.

PTM/Processing

This section describes post-translational modifications (PTMs) and/or processing events.

Features

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200400600
Domains & sites
Molecule processing
PTM
Sequence information
Structural features
PDBe 3D structure coverage
Topology
Mutagenesis
Proteomics
Antigenic sequences
Variants
200400600
Source Identifier Method Resolution Chain Positions Links
PDB 1AAP X-ray 1.50 Å A/B 287-344 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1AMB NMR A 672-699 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1AMC NMR A 672-699 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1AML NMR A 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1BA4 NMR A 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1BA6 NMR A 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1BJB NMR A 672-699 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1BJC NMR A 672-699 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1BRC X-ray 2.50 Å I 287-342 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1CA0 X-ray 2.10 Å D/I 289-342 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1HZ3 NMR A 681-706 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1IYT NMR A 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1MWP X-ray 1.80 Å A 28-123 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1OWT NMR A 124-189 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1QCM NMR A 696-706 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1QWP NMR A 696-706 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1QXC NMR A 696-706 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1QYT NMR A 696-706 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1TAW X-ray 1.80 Å B 287-344 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1TKN NMR A 460-569 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1X11 X-ray 2.50 Å C/D 754-766 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1Z0Q NMR A 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1ZE7 NMR A 672-687 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1ZE9 NMR A 672-687 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 1ZJD X-ray 2.60 Å B 289-344 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2BEG NMR A/B/C/D/E 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2BP4 NMR A 672-687 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2FJZ X-ray 1.61 Å A 133-189 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2FK1 X-ray 1.60 Å A 133-189 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2FK2 X-ray 1.65 Å A 133-189 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2FK3 X-ray 2.40 Å A/B/C/D/E/F/G/H 133-189 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2FKL X-ray 2.50 Å A/B 124-189 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2FMA X-ray 0.85 Å A 133-189 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2G47 X-ray 2.10 Å C/D 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2IPU X-ray 1.65 Å P/Q 672-679 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2LFM NMR A 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2LLM NMR A 686-726 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2LMN NMR A/B/C/D/E/F/G/H/I/J/K/L 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2LMO NMR A/B/C/D/E/F/G/H/I/J/K/L 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2LMP NMR A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2LMQ NMR A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2LNQ NMR A/B/C/D/E/F/G/H 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2LOH NMR A/B 686-726 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2LP1 NMR A 671-770 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2LZ3 NMR A/B 699-726 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2LZ4 NMR A/B 699-726 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2M4J NMR A/B/C/D/E/F/G/H/I 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2M9R NMR A 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2M9S NMR A 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2MGT NMR A/B 672-687 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2MJ1 NMR A 688-705 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2MPZ NMR A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a 686-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2MVX NMR A/B/C/D/E/F/G/H/I/J 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2MXU NMR A/B/C/D/E/F/G/H/I/J/K/L 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2NAO NMR A/B/C/D/E/F 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2OTK NMR C 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2R0W X-ray 2.50 Å Q 672-679 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2WK3 X-ray 2.59 Å C/D 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2Y29 X-ray 2.30 Å A 687-692 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2Y2A X-ray 1.91 Å A 687-692 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2Y3J X-ray 1.99 Å A/B/C/D/E/F/G/H 701-706 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2Y3K X-ray 1.90 Å A/B/C/D/E/F/G/H 706-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 2Y3L X-ray 2.10 Å A/B/C/G 706-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3AYU X-ray 2.00 Å B 586-595 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3BAE X-ray 1.59 Å A 672-699 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3BKJ X-ray 1.59 Å A 672-687 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3DXC X-ray 2.10 Å B/D 739-770 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3DXD X-ray 2.20 Å B/D 739-770 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3DXE X-ray 2.00 Å B/D 739-770 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3GCI X-ray 2.04 Å P 707-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3IFL X-ray 1.50 Å P 672-678 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3IFN X-ray 1.50 Å P 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3IFO X-ray 2.15 Å P/Q 672-678 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3IFP X-ray 2.95 Å P/Q/R/S 672-678 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3JQ5 X-ray 2.03 Å B 672-679 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3JQL X-ray 1.20 Å B 687-692 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3JTI X-ray 1.80 Å B 699-706 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3KTM X-ray 2.70 Å A/B/C/D/E/F/G/H 18-190 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3L33 X-ray 2.48 Å E/F/G/H 290-341 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3L81 X-ray 1.60 Å B 761-767 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3MOQ X-ray 2.05 Å A/B/C/D 689-712 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3MXC X-ray 2.00 Å L 754-762 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3MXY X-ray 2.30 Å L 754-762 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3NYJ X-ray 3.20 Å A 365-567 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3NYL X-ray 2.80 Å A 365-570 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3OVJ X-ray 1.80 Å A/B/C/D 687-692 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3OW9 X-ray 1.80 Å A/B 687-692 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3PZZ X-ray 1.29 Å A/B 700-705 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3Q2X X-ray 1.45 Å A 698-703 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3SV1 X-ray 3.30 Å D/E/F 754-767 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3U0T X-ray 2.50 Å E/F 701-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3UMH X-ray 2.00 Å A 370-575 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3UMI X-ray 2.40 Å A 370-575 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 3UMK X-ray 2.60 Å A 370-575 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4HIX X-ray 2.20 Å A 672-699 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4JFN X-ray 1.75 Å A 23-185 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4M1C X-ray 3.50 Å G/H 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4MDR X-ray 1.85 Å B 758-767 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4MVI X-ray 1.70 Å B 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4MVK X-ray 1.50 Å B 689-694 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4MVL X-ray 2.30 Å E/F/G/H 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4NGE X-ray 2.70 Å B/E 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4OJF X-ray 2.00 Å A 672-679 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4ONF X-ray 2.00 Å P 672-678 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4ONG X-ray 2.20 Å P 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4PQD X-ray 1.33 Å A 22-126 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4PWQ X-ray 1.40 Å A/B 18-190 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 4XXD X-ray 2.41 Å C/F 683-699 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5AEF EM 5.00 Å A/B 686-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5AM8 X-ray 1.90 Å P/Q/R/S 675-681 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5AMB X-ray 1.55 Å P/Q 706-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5BUO X-ray 2.31 Å A/B 370-710 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5C67 X-ray 1.83 Å C/E 294-344 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5CSZ X-ray 1.80 Å D/E 672-682 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5HOW X-ray 2.29 Å A/B/C/D/E/F 688-705 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5HOX X-ray 1.90 Å A/B/C/D/E/F 688-707 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5HOY X-ray 2.29 Å A/B/C/D/E/F 688-707 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5KK3 NMR A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5LFY NMR A/B 672-681 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5LV0 X-ray 2.70 Å C/D 706-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5MY4 X-ray 2.21 Å C 674-683 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5MYO X-ray 1.59 Å E 674-683 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5MYX X-ray 1.49 Å E/F 674-689 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5ONP X-ray 1.34 Å B 700-704 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5ONQ X-ray 1.17 Å B 700-704 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5OQV EM 4.00 Å A/B/C/D/E/F/G/H/I 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5TXD X-ray 1.45 Å Z 698-703 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5VOS EM 1.42 Å A 695-705 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5VZY X-ray 2.32 Å A 682-696 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 5W3P X-ray 1.92 Å P 672-687 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6CO3 X-ray 2.38 Å Q 672-682 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6GFI X-ray 2.30 Å C/E 294-346 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6ITU X-ray 2.17 Å B 755-766 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6IYC EM 2.60 Å E 688-770 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6NB9 EM 1.05 Å A 691-705 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6O4J EM 1.40 Å A/B 687-697 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6OC9 NMR A/B/C/D/E/F/G/H/I/J 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6OIZ EM 1.10 Å A 691-705 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6RHY NMR A/B/C/D 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6SHS EM 4.40 Å A/B/C/D/E/F/G/H/I/J/K/L 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6SZF NMR A 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6TI5 NMR A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6TI6 NMR PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6TI7 NMR PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6W0O Other 2.77 Å 1/2/3/4/5/6 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6WXM X-ray 2.30 Å A/B/C/D/E/F/G/H/I/J/K 685-706 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6XOV EM 3.30 Å B 672-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6YHF NMR A 697-726 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6YHI NMR A 697-726 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6YHO NMR A 697-726 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6YHP NMR A 697-726 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 6YHX NMR A 697-726 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 7B3J NMR A 672-726 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 7B3K NMR A 672-726 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 7E6P X-ray 2.50 Å A 686-701 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 7JXN X-ray 2.00 Å A/B/C/D 686-706 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 7JXO X-ray 2.81 Å A/B/C 686-706 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 7O1Q EM 3.40 Å A/B/C/D/E/F/G 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 7OW1 X-ray 1.40 Å A 674-685 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 7OXN X-ray 2.50 Å A 672-685 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 7Q4B EM 2.50 Å A/B/C/D/E/F/G/H/I/R 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 7Q4M EM 2.80 Å A/B/C/D/E/F/G/H/I/J 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 7RTZ X-ray 2.10 Å A/B 682-711 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 7WVY EM 3.00 Å L 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 8AZS EM 2.90 Å H 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
PDB 8AZT EM 3.70 Å B 672-713 PDBe · RCSB-PDB · PDBj · PDBsum /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg
AlphaFold AF-P05067-F1 Predicted 1-770 AlphaFold /static/media/download.72eb037e0103b39b935aa5c66f854c5f.svg

Glycans

There are currently no glycans associated with the protein.

Expression

Abundance and localization of gene products based on both RNA and immunohistochemistry data from the Human Protein Atlas. Click on the tissue names to view primary data.

RNA Expression (NX)Protein Localization (score)Adipose tissueAdrenal glandAmygdalaAppendixBasal gangliaBone marrowBreastBronchusCaudateCerebellumCerebral cortexCervixChoroid plexusColonDuodenumEndometrium 1Endometrium 2EpididymisEsophagusFallopian tubeGallbladderHeart muscleHippocampal formationHippocampusHypothalamusKidneyLiverLungLymph nodeMedulla oblongataMidbrainNasopharynxOral mucosaOvaryPancreasParathyroid glandPituitary glandPlacentaPonsProstateRectumRetinaSalivary glandSeminal vesicleSkeletal muscleSkin 1Skin 2Small intestineSmooth muscleSoft tissue 1Soft tissue 2Spinal cordSpleenStomach 1Stomach 2TestisThalamusThymusThyroid glandTonsilUrinary bladderVaginaWhite matter4.52.42.61.6620.840.70043.26.514.958.13.61.6016.78.77.81.84.25.704.311.65.88.13.23.12.3006.810.43.41.64.432.92.11.54.71.20.216.604.80.60029.85.3055.29.85.80.82.217.518.4highhigh0high0highhighmediumhighhighhighhigh0highhighhighhighhighhighhighhighhigh0high0highhighhighhigh00highhighhighhighhigh0high0mediumhigh0highhighmediumhighhighhighhighmediummedium0highhighhighhigh00highhighmediumhigh0

Proteomics

Tissue IDTissue TermDisease StateIsoformExperiment CountPeptide CountAbundance Score
BTO:0001202SalivaDisease free
Sjogren's Syndrome
COVID-19		50
2
8		133
2870
24		430.74
1008.23
0
BTO:0001316Submandibular glandDisease free49244213513.97
BTO:0001315Sublingual glandDisease free49244214,385.84
BTO:0001004Parotid glandDisease free5612083,127.74

Cross References

RefSeqNP_003504.2, NP_066390.1
PeptideAtlasP04908
EnsemblENST00000303910.5, ENST00000615868.2, ENSG00000277075
GeneCardsH2AC4, H2AC8

Keywords

3D-structure, Acetylation, Chromosome, Citrullination, DNA-binding, Hydroxylation, Isopeptide bond, Methylation, Nucleosome core, Nucleus, Phosphoprotein, Reference proteome, Ubl conjugation

References

1.

Zhong R, et al. (1983) The primary structure and expression of four cloned human histone genes.Nucleic Acids Res. 11(21):7409-25

[PubMed:6647026]

2.

Albig W, et al. (1991) Isolation and characterization of two human H1 histone genes within clusters of core histone genes.Genomics. 10(4):940-8

[PubMed:1916825]

3.

Albig W,Doenecke D (1997) The human histone gene cluster at the D6S105 locus.Hum Genet. 101(3):284-94

[PubMed:9439656]

4.

Marzluff WF, et al. (2002) The human and mouse replication-dependent histone genes.Genomics. 80(5):487-98

[PubMed:12408966]

5.

Mungall AJ, et al. (2003) The DNA sequence and analysis of human chromosome 6.Nature. 425(6960):805-11

[PubMed:14574404]

6.

Gerhard DS, et al. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).Genome Res. 14(10B):2121-7

[PubMed:15489334]

7.

Aihara H, et al. (2004) Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo.Genes Dev. 18(8):877-88

[PubMed:15078818]

8.

Zhang Y, et al. (2004) Phosphorylation of histone H2A inhibits transcription on chromatin templates.J Biol Chem. 279(21):21866-72

[PubMed:15010469]

9.

Wang H, et al. (2004) Role of histone H2A ubiquitination in Polycomb silencing.Nature. 431(7010):873-8

[PubMed:15386022]

10.

Galasinski SC, et al. (2002) Global regulation of post-translational modifications on core histones.J Biol Chem. 277(4):2579-88

[PubMed:11709551]

11.

Hagiwara T, et al. (2005) Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes.Biochemistry. 44(15):5827-34

[PubMed:15823041]

12.

Cao R, et al. (2005) Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.Mol Cell. 20(6):845-54

[PubMed:16359901]

13.

Bergink S, et al. (2006) DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.Genes Dev. 20(10):1343-52

[PubMed:16702407]

14.

Boyne MT 2nd, et al. (2006) Precise characterization of human histones in the H2A gene family by top down mass spectrometry.J Proteome Res. 5(2):248-53

[PubMed:16457589]

15.

Mailand N, et al. (2007) RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.Cell. 131(5):887-900

[PubMed:18001824]

16.

Huen MS, et al. (2007) RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.Cell. 131(5):901-14

[PubMed:18001825]

17.

Stewart GS, et al. (2009) The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.Cell. 136(3):420-34

[PubMed:19203578]

18.

Doil C, et al. (2009) RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.Cell. 136(3):435-46

[PubMed:19203579]

19.

Tan M, et al. (2011) Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.Cell. 146(6):1016-28

[PubMed:21925322]

20.

Mattiroli F, et al. (2012) RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.Cell. 150(6):1182-95

[PubMed:22980979]

21.

Gatti M, et al. (2012) A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase.Cell Cycle. 11(13):2538-44

[PubMed:22713238]

22.

Xie Z, et al. (2012) Lysine succinylation and lysine malonylation in histones.Mol Cell Proteomics. 11(5):100-7

[PubMed:22389435]

23.

Kim K, et al. (2013) VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription.Mol Cell. 52(3):459-67

[PubMed:24140421]

24.

Dai L, et al. (2014) Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.Nat Chem Biol. 10(5):365-70

[PubMed:24681537]

25.

Tessarz P, et al. (2014) Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.Nature. 505(7484):564-8

[PubMed:24352239]

26.

Bhatnagar S, et al. (2014) TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.Nature. 516(7529):116-20

[PubMed:25470042]

27.

Wang Z, et al. (2016) USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response.Genes Dev. 30(8):946-59

[PubMed:27083998]

28.

Xie Z, et al. (2016) Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation.Mol Cell. 62(2):194-206

[PubMed:27105115]

29.

Bao X, et al. (2019) Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics.Mol Cell. 76(4):660-675.e9

[PubMed:31542297]

30.

Kujirai T, et al. (2016) Structure and function of human histone H3.Y nucleosome.Nucleic Acids Res. 44(13):6127-41

[PubMed:27016736]

31.

Cao D, et al. (2020) Structural basis for nucleosome-mediated inhibition of cGAS activity.Cell Res. 30(12):1088-1097

[PubMed:33051594]

32.

Kujirai T, et al. (2020) Structural basis for the inhibition of cGAS by nucleosomes.Science. 370(6515):455-458

[PubMed:32912999]

Entry Information

Created On8-13-1987
Last Modified On2-22-2023